Search results for " infiltration"

Non-eosinophilic Airway Hyper-reactivity in Mice, Induced by IFN-γProducing CD4+and CD8+Lung T cells, is Responsive to Steroid Treatment

2014

Non-eosinophilic asthma is characterized by infiltration of neutrophils into the lung and variable responsiveness to glucocorticoids. The pathophysiological mechanisms have not been characterized in detail. Here, we present an experimental asthma model in mice associated with non-eosinophilic airway inflammation and airway hyper-responsiveness (AHR). For this, BALB/c mice were sensitized by biolistic DNA immunization with a plasmid encoding the model antigen β-galactosidase (pFascin-βGal mice). For comparison, eosinophilic airway inflammation was induced by subcutaneous injection of βGal protein (βGal mice). Intranasal challenge of mice in both groups induced AHR to a comparable extent as w…

Source shape and data analysis procedure effects on hydraulic conductivity of a sandy-loam soil determined by ponding infiltration runs

2017

Performing ponding infiltration runs with non-circular sources could represent a good means to sample completely an area of interest. Regardless of the shape of the source, predicting the expected reliability of the collected data by infiltrometers should facilitate soil hydraulic characterisation and also allow a more conscious use of the field data. The influence of the shape of the infiltration source (i.e., circular or square) and the analysis procedure of the steady-state infiltration data on the saturated hydraulic conductivity, Ks, of a sandy-loam soil was tested in this investigation. Circular and square surfaces sampled with the pressure infiltrometer (PI) yielded similar estimates…

Conservative Surgery of Renal Carcinoma: The EIRSS Experience

1981

Summary— Seventy-two patients with renal carcinoma (RC) in a solitary kidney or bilateral synchronous tumours underwent parenchyma-sparing excision of their neoplasms. This was performed in situin 51 and extracorporeally in 21 kidneys, with a complication rate respectively of 1 7 and 43%. The 5-year survival rates were 78% for unilateral disease, 48% for bilateral synchronous and 38% for bilateral asynchronous disease. Survival correlated with Pcategory, grade and diameter of the tumour. Vascular invasion and spindle cells indicated a poor prognosis; the position of the tumour, oncocytic elements, calcification, lymphocytic infiltration or the predominance of clear cell or granular cells di…

Development and analysis of the Soil Water Infiltration Global database

2018

27 Pags.- 11 Tabls.- 8 Figs. © Author(s) 2018. This work is distributed under the Creative Commons Attribution 4.0 License.

EVALUATION OF THE EFFECTS OF CONTI- NUOUS PREPERITONEAL WOUND INFILTRATION ON POSTOPERATIVE RESPIRATORY PERFORMANCE IN PATIENTS WHO UNDERWENT MAJOR A…

2013

Aim. According to the recent literature, continuous pre-perito- neal wound infiltration with local anaesthetics (CPWI) is an effective analgesic therapy in patients who undergo major abdominal surgery 1. Although it is not inferior to other com- monly used techniques in postoperative analgesia, many studies report conflictive results about its efficacy compared to them 2. The aim of our study was to evaluate the effects of CPWI on the postoperative respiratory performance in patients after major abdominal surgery. Materials and methods. From June 2011 to July 2012, a total of 14 patients have been evaluated. All patients were treated using the protocol generally used in our Department for t…

The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment.

2011

Background: Cannabinoids are known to reduce intestinal inflammation. Atypical cannabinoids produce pharmacological effects via unidentified targets. We were interested in whether the atypical cannabinoid O-1602, reportedly an agonist of the putative cannabinoid receptor GPR55, reduces disease severity of dextran sulfate sodium (DSS) and trinitrobenzene sulfonic acid (TNBS)-induced colitis in C57BL/6N and CD1 mice. Methods: DSS (2.5% and 4%) was supplied in drinking water for 1 week while TNBS (4 mg) was applied as a single intrarectal bolus. Results: Both treatments caused severe colitis. Injection of O-1602 (5 mg/kg intraperitoneally) significantly reduced macroscopic and histological col…

Co-morbidities in patients with hip osteoarthritis and treated with ecoguided infiltrations of Hyaluronic acid: study of the effectiveness of the tre…

2014

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature

2015

AbstractNeutrophil extracellular traps (NETs) composed of DNA decorated with histones and proteases trap and kill bacteria but also injure host tissue. Here we show that during a bloodstream infection with methicillin-resistant Staphylococcus aureus, the majority of bacteria are sequestered immediately by hepatic Kupffer cells, resulting in transient increases in liver enzymes, focal ischaemic areas and a robust neutrophil infiltration into the liver. The neutrophils release NETs into the liver vasculature, which remain anchored to the vascular wall via von Willebrand factor and reveal significant neutrophil elastase (NE) proteolytic activity. Importantly, DNase although very effective at D…

Articaine versus lidocaine inferior alveolar nerve block in posterior mandible implant surgeries: a randomized controlled trial

2023

Background: The aim of this study is to compare the effects of %4 articaine and %2 lidocaine on inferior alveolar nerve block (IANB) for implant surgery in the posterior mandible.Material and Methods: The patients who have inserted implants in the posterior mandible were divided into 2 groups for IANB: lidocaine and articaine. VAS = visual analog scale, pain during surgery and injection, lip numb-ness time, mandibular canal-implant apex distance, age, gender, bone density, implant number, release incision, adjacent teeth, and duration of surgery were analyzed using t-test, Mann-Whitney U test, Spearman's coefficient, and, Pearson's chi-squared test. This trial followed the recommendations o…

Multiple Non-linear Reservoirs to Model Water Balance Components in Sandy Soils

2023

In the hydrologic literature, to model water flow in unsaturated soils, the Richards equation is usually applied, allowing the main components of the hydrologic cycle, as rainfall partitioning into surface runoff and infiltration, to be determined. The Richards equation is highly nonlinear, making very challenging to derive analytical solutions. Recently, for constant rainfall intensity, under the simplified hypothesis of gravity-driven infiltration, and by assuming a capacitance framework, a simplified solution of the Richards equation that considers the Brooks and Corey hydraulic conductivity function was suggested. By maintaining the assumption that the infiltration process is dominated …